ELN and myocardial ischemia: [38] The miR-29 family includes 3 members expressed from a bicistronic cluster with miR-29a coexpressed with miR-29b-1, and miR-29b-2 coexpressed with miR-29c. All three miR-29 family members are downregulated with myocardial ischemia-reperfusion in mice and humans, particularly in the border zone. [25] A number of fibrosis-related genes are targeted by miR-29, including collagens, fibrillins, and elastin to induce cardiac fibrosis. In vivo inhibition of miR-29 with an antagomir, an oligonucleotide complementary to miR-29b (anti-miR-29b), activates collagen expression [25].