ANXA3 and hyperopia: For the locus on chromosome 4 that showed some evidence of association with hyperopia in our data, Kiefer et al.[18] suggested that ANTXR2 (MIM:106490), a gene involved in extracellular matrix adhesion was the best candidate, but other good candidates exist in this region such as BMP2 inducible kinase (BMP2K) and annexin A3 (ANXA3, MIM:106490) a gene involved in regulation of cell growth and signal transduction pathways.