After all quality control measures and appropriate association analyses, genome-wide association results from Caucasian participants in the AREDS, KORA, FES, OGP-Talana, MESA, RSI, RSII, RSIII and ERF studies were combined in a genome-wide discovery meta-analysis totaling 16,830 individuals for myopia and 14,981 individuals for hyperopia. The gene discussed is ERF; the disease is hyperopia.