E2F1 and breast cancer: Table 3 summarizes the top 30 genes that are involved in the selected pathways. They are ranked by weighted sum of both occurrences in selected pathways (counts) and weights measured by the hazard ratio of each pathway. Among them, many genes encode protein kinases that are well-known to be involved in breast cancers, such as PRKACB, PRKACG, MAPK1 and CALM1. Some other genes encode transcription factors that are well-known for their close relationship to cancer, such TP53, RB1, HRAS, RAF1, GRB2, E2F1, and SRC [32],[42]–[44].