Interestingly, KEGG_MELANOGENESIS is selected as a feature, probably due to inclusion of many cancer relevant genes in this pathway: such as protein kinase genes PRKACB, PRKACG, PRKCB, PRKCA; phosphorylase kinase genes CALM1, CALM2, CALM3; G-protein related gene GNAQ, HRAS; mitogen-activated protein kinases MAPK1, MAPK3, MAP2K1; and other oncogenes like RAS [31],[32]. This evidence concerns the gene CALM2 and cancer.