UCN3 and diabetes mellitus: Quantitative RT-PCR analyses on islets at different time point during the development of S961-induced diabetes and its subsequent recovery showed that the levels of Ucn3 mRNA are significantly (p > 0.005) reduced to about half of the levels in control mice as early as 4 days after S961 induction and are down to about a third by day 7 (Figure 2B).