HLA-C and psoriasis: Nair et al. [5] completely sequenced the PSORS1 region for one psoriatic individual and four controls, genotyped risk alleles in 678 psoriatic families, and employed three computational haplotype reconstruction methods as well as a combinatorial analysis to implicate the HLA-Cw6 haplotype as the most probable source of susceptibility within the PSORS1 locus for early-onset psoriasis of individuals with European ancestry.