CAD and gastric cancer: For example, for the CAD gene which catalyzing L-glutamine, 2866 potential promiscuity catalytic reactions associated with 170 substrates and 1644 products were predicted in CAD mutant lung (SCC) cancer and gastric cancer (Table S8 in Text S1, Figure 5B, all detailed information of predicted promiscuity reactions is shown in the File S2).