While the divergent trends of gcnt3 and mgat5b between non-metastatic and metastatic HCC clinical cancer specimens were statistically significant (P = 0.002, P = 0.04, respectively) and they were all up-regulated in metastatic HCC clinical cancer specimens, which trends were as same as in human HCC cell lines and their orthotopic xenograft tumors. This evidence concerns the gene MGAT5B and hepatocellular carcinoma.