MET and adenocarcinoma: We found a negative net effect of MET gene copy number on survival in studies with Asian populations (HR = 2.31 95% CI 1.31–3.79), in studies where the reported histology was adenocarcinoma in more than half of the cases (HR = 1.55 95% CI 1.23–1.94), in studies which used FISH (HR = 1.48 95% CI 1.06–2.06) and in studies where the patients were diagnosed before 2004 (HR = 1.70 95% CI 1.34–2.16) (table 2).