NFKB1 and cardiac hypertrophy: Overexpression of miR-142, another miR that we found upregulated by AM in CStC, has been shown to be inversely related to MAPK activity in cultured cardiac myocytes, inhibiting both survival and growth pathways and repressing multiple components of the NF-κB pathway, and to induce extensive apoptosis and cardiac dysfunction in a model of cardiac hypertrophy [54].