Histopathologic examination of the lungs of Nlrc4−/− and Casp1−/−Casp11−/− mice 24 hours after airborne infection with B. pseudomallei showed relatively similar sized neutrophilic infiltrates and percent of lung involved in these mice compared to wild type mice although there was minor variation in morphologic features, such as earlier evidence of nuclear fragmentation in Casp1−/−Casp11−/− mice (Figure 4). This evidence concerns the gene NLRC4 and infection.