PTEN and B-cell chronic lymphocytic leukemia: Dramatically overexpression without genomic loci amplification: dysregulation at post- or transcriptional level [137]High expression is a significantly unfavourable P independent of other clinic-pathological factors in B-CLL patients [156]Can trigger B-lymphomagenesis by targeting ANP32A, SMAR-CA4 and PTEN [157,158]