NPM1 and anaplastic large cell lymphoma: Finally, the role of miR-29a was also demonstrated in ALK-positive (ALK+) anaplastic large cell lymphomas (ALCL) which overexpress the major antiapoptotic protein MCL-1. Desjobert et al. [89] showed in ALK+ALCL cell lines and 20 biopsy specimens a low expression of miR-29a playing an important regulatory role in MCL-1 and that this down-modulation required an active NPM-ALK Kinase as in transgenic mice and mouse embryonic fibroblast (MEF) cells the absence of NPM-ALK resulted an increase of miR-29a expression.