PRDM1 and Hodgkins lymphoma: Their overexpression implicates down-regulation of PRDM1/BLIMP1, a master regulator for B-cell terminal differentiation that acts as a tumor suppressor gene also in non-GC-DBLCL, particularly in ABC-DBLCL, and anaplastic large T-cell lymphoma [56,102] Indeed, Nie et al. [86] demonstrated that PRDM1/blimp1 was down regulated by miR-9 and let-7a in Hodgkin/Reed-Sternberg (HRS) cells of HL.