The prognostic significance of Tcl1 levels has also been verified in transgenic mice models [181], and is further supported by the observation that high Tcl1 levels are associated with the presence of well-known “poor prognosis” markers such as ZAP-70 and unmutated IgVH status in B-CLL patients [179]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.