ZAP70 and B-cell chronic lymphocytic leukemia: They investigated whether a specific miRNA signature was associated with four subgroups of 94 B-CLL patients with different clinical courses: group 1 (expression of ZAP-70 and unmutated IgVH), group 2 (expression of ZAP-70 and mutated IgVH ), group 3 (no expression of ZAP-70 and unmutated IgVH ), and group 4 (no expression of ZAP-70 and mutated IgVH ).