AKT1 and mantle cell lymphoma: In another study, as previously mentioned Rao et al. [37] demonstrated that the overexpression of miRNA-17-92 cluster in MCL by directly targeting PHLPP2, in addition to PTEN and BIM, inhibited chemotherapy-induced apoptosis and enhanced tumor growth via PI3K/AKT pathway activation, as PHLPP2 was a negative regulator of this pathway.