Growth suppressive function and pro-apoptotic effect in pro-B cells of which it controls the transition to pre-B stage by targeting FOXP1 [77,78] know as B cell on cogene. [79]It is negatively regulated by c-MYC [80] and positively regulated by TP53 [80,81,82,83,84].In turn, by inhibiting SIRT1, it actives TP53 resulting apoptotic effects mediated by TP53/SIRT1/miR-34a pathway.Epigenetically silenced in many lymphomas, mainly NK/T-NHL [55]. This evidence concerns the gene SIRT1 and non-Hodgkin lymphoma.