Specifically Zhang et al. [175] investigated the mechanisms of miR-15a/16-1 transcriptional repression and its epigenetic regulation by c-MYC and histone deacetylase 3 (HDAC) in MCL, highlighting the existence of another important mechanism responsible for the down-regulation of miR-15a/16-1 expression in addition to 13q14 deletion. This evidence concerns the gene HDAC3 and mantle cell lymphoma.