Recently it has been demonstrated that the miR-17-92 cluster mediates chemo- and radio-resistance, as well as enhances tumor growth in MCL by activating the PI3K/AKT pathway trough the suppression of the PH domain and Leucine rich repeat Protein Phosphatases (PHLPP2) an important negative regulator of the PI3K/AKT pathway [37,152] This therefore suggests that another mechanism of action mediated by the miR-17-92 cluster is to promote cell growth by targeting PHLPP2 in addition to PTEN, Bim and MYC/E2F1 [37]. The gene discussed is AKT1; the disease is mantle cell lymphoma.