Interestingly, it has been shown that the high expression of CD10, a specific key marker of GC-DBLCL, is conversely down-regulated or absent in ABC-DBLCL cells in which there is simultaneously the aberrantly constitutive activation of the NF-κB pathway and the constitutive overexpression of miR-155 with low expression levels of PU.1 [140]. The gene discussed is SPI1; the disease is aneurysmal bone cyst.