MCL1 and anaplastic large cell lymphoma: miR-29a targets MCL-1 that could promote tumor cell survival by inhibiting apoptosis. This down-modulation requires an active NPM-ALK Kinase since the absence of kinase results an increase of miR-29a expression. In ALCL cell lines and in a xenografted model the increased expression of miR-29a modulated apoptosis through inhibition of MCL-1 expression, with a concomitant tumor growth reduction suggesting a potential new tool to affect tumorigenesis in these lymphomas [89].