HDAC9 and B-cell non-Hodgkin lymphoma: Since the regulatory mechanism of miR-15a/16-1 was further demonstrated in BL, it is conceivable that the c-MYC-induced miR-15a/16-1 changes by HDAC may be a novel mechanism for MYC-driven miRNA suppression and malignant transformation in aggressive B-cell lymphoma [175].