More specifically, acidic nuclear phosphoprotein 32 family member A (ANP32A), Swi/Snf related, matrix associated, actin dependent regulator of chromatin A4 (SMAR-CA4) and PTEN are validated targets of miR-21 mainly in B-cell lymphoma [158], whereas PTEN and programmed cell death 4 (PDCD4) are involved in NK/T cell Lymphoma [159,160]. Here, PDCD4 is linked to T-cell non-Hodgkin lymphoma.