Similarly, Jiang et al. [152] demonstrated that the over expression of miR-17-92 significantly increased the radio-resistance of human MCL cells via PI3K/AKT pathway by targeting PTEN and PHLPP2. They showed that the overexpression of this miRNA significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells Z138c after different doses of radiation. The gene discussed is AKT1; the disease is mantle cell lymphoma.