NOS3 and endothelial dysfunction: Also, activation of AT2 receptor results in increased production of nitric oxide by endothelial Nitric Oxide Synthase (eNOS) in endothelial cells (Yayama and Okamoto, 2008), which could be protective against cerebral malaria since low nitric oxide bioavailability may exacerbate endothelial dysfunction and contributes to the pathogenesis of severe malaria (Gramaglia et al., 2006; Miller et al., 2013).