MEFV and hereditary spastic paraplegia: In the present study, mutations detected in 34 (91.8%) of HSP patients were heterozygous ,while only 3(8.1%) had compound heterozygous MEFV mutations, which is consistant with the results of Bayram et al. [11] in which (70%) of HSP patients with MEFV mutations had heterozygous mutations, 12.7% had compound heterozygous mutations and 17% had homozygous mutations.