Gos is a natural BH3 mimetics, acting as a small molecule inhibitor for the interaction between anti-apoptotic Bcl-2/Bcl-XL/Mcl-1 and pro-apoptotic BH3-only proteins such as BIM, BID, BAD or BIK, thereby induces apoptosis in cancer cells (18). This evidence concerns the gene BCL2 and cancer.