We found that PC3 and MCF7 tumor cells dramatically increased phosphorylation of LCK, PKA, and CREB in senescent CD4+ T cells, suggesting that tumor cell treatment induced LCK inhibitory signaling in senescent T cells (Fig 4D) (Tasken & Stokka, 2006; Vang et al, 2001). This evidence concerns the gene LCK and neoplasm.