In addition, pretreatment of tumor cells with forskolin, a cAMP-elevating agent (Bopp et al, 2007), or 3-isobutyl-1-methylxanthine (IBMX), an inhibitor for cAMP monophosphate phosphodiesterase (PDE) (Grader-Beck et al, 2003), significantly promoted the induction of naïve T-cell senescence co-cultured with the pretreated tumor cells (Supplementary Fig S5A). Here, ALDH7A1 is linked to neoplasm.