TLR8 and neoplasm: Notably, we did not observe any direct effects on tumor growth in multiple types of tumor cells mediated by TLR8 ligand Poly-G3 in vitro and in vivo, unlike the results seen with other TLR ligands, such as Poly (I:C) and CpG (Liang et al, 2010; Salaun et al, 2007).