However, in this model combining tauopathy and amyloidosis, the anatomic pattern and time course of changes in Aβ and tau were distinct [96], and treatment with a γ‐secretase inhibitor blocked posttraumatic Aβ accumulation but had no effect on tau pathology suggesting that once initiated these two pathologies may take independent courses of progression [96]. This evidence concerns the gene MAPT and tauopathy.