NUCLEOLIN and hepatocellular carcinoma: Furthermore, the Cox proportional hazards model showed that nucleolin expression was an independent poor prognostic factor for both 5-year disease-free survival (hazards ratio [HR] = 3.696, 95% confidence interval [CI] = 1.662-8.138, P = 0.01, Table 2) and 5-year overall survival (HR = 3.872, CI = 1.681-8.392, P = 0.01, Table 2) in HCC.