In early-onset preeclampsia, between 20 + 0 and 33 + 6 weeks of gestation, an sFlt-1/PlGF ratio of ≤33 was negative, and an sFlt-1/PlGF ratio of ≥85 was positive for confirmation of preeclampsia or HELLP syndrome, with a sensitivity/specificity of 95%/94% and 88%/99%, respectively. The gene discussed is PGF; the disease is preeclampsia.