Moreover, CD47 expression strongly associated with the presence of lymph node metastasis: 9/14 (64.3%) patients had lymph node metastases in the CD47 positive group versus 92/245 (37.6%) in the CD47 negative group (Cochran-Armitage test for trends, p=0.01). This evidence concerns the gene CD47 and metastatic malignant neoplasm in the lymph nodes.