PPARG and breast cancer: These data suggest that substitution of lysyl residues with residues that cannot be acetylated (alanine (K to A) or glutamine (K to Q)) represents PPARγ acetylation-defective mutant in and that Pparγ acetylation at the conserved lysine motif serves as a molecular switch of Pparγ-mediated induction of lipogenesis in breast cancer cells.