BCL2 and head and neck cancer: We report the ability of P(EAA-co-BMA)-b-PNASI-g-P(HMA-co-TMAEMA) polymer to condense anti-Bcl-2 siRNA into “smart” particles that deliver their cargo past the endosomal membrane and into the cytoplasm of HeLa cervical cancer and UM-SCC-17B head and neck cancer cells to knockdown the expression of anti-apoptotic Bcl-2 protein at the mRNA and protein levels.