Likewise, NAE1, UBA3 and UBC12 were scored as high intensities in 70.5% (227/322; moderate, n=134; strong, n=93), 67.1% (216/322; moderate, n=159; strong, n=57), and 72.0% (232/322; moderate, n=133; strong, n=99) of ICC cases, respectively (Fig. 1A-B). This evidence concerns the gene UBA3 and intrahepatic cholangiocarcinoma.