In our recent paper [19], [20], we have reported that cCSE induces the plasma membrane damage and cell death in cultured C6 glioma cells, and that total of the plasma membrane damage and part of cell death are induced by ROS which are produced by PKC-dependent activation of NADPH oxidase (NOX), based on the sensitivities to a PKC inhibitor (BIS I) and a NOX inhibitor (DPI). This evidence concerns the gene FMO5 and central nervous system cancer.