Using subnetwork enrichment analysis (Figure 5B), we identified eight CMAH downstream-localized proteins (ERBB2, CMAS, CYB5R3, CTNNB1, IL4, IL17A, IL6, and IFNG), six small molecules (Fe2+, NSC2921, sialate, CMP-N-glycolylneuraminate, N-glycolylneuraminate, CMP-N-acetylneuraminate), three cell processes (immune reactivity, B-cell activation, cell growth), and two diseases (metabolic disease and Duchenne muscular dystrophy). This evidence concerns the gene CYB5R3 and metabolic disease.