Of them, specific disorders in Cmah null mice were closely associated with cardiovascular disease (Ptgds, Scd, and Egrl)-, skeletal and muscular disease (Adh1c, Dbp, Dkk3, Egr1, Herpud1, Scd, Snca, Ptgds, Timp4, Myl4, Alas2, and Fkbp5)-, and cancer (Cfd, Egr1, Scd, Timp4, Per2, Scgb1a1, Spon2, Slc46a3, and Gck)-associated genes in heart (Table 3). This evidence concerns the gene PER2 and cardiovascular disorder.