MYD88 and diffuse large B-cell lymphoma: Alternatively, in diffuse large B cell lymphomas (DLBCL), the activated B cell (ABC) phenotype features NF-κB activation due to somatic mutations at various levels of the BCR or TLR signaling cascades (Igα, Igβ, CARD11, Myd88...) and results in chronic BCR signaling in the absence of any BCR ligand [11, 12].