This could also be pertinent to the observations made in patients, where IgM expressing malignancies are usually more aggressive than related class-switched proliferations, as noticed for the rare IgM myelomas, with lymphoplasmacytic rather than plasmacytic proliferations or as noticed for DLBCL, where the worse prognosis associates with the IgM-expressing ABC-type. Here, CD40LG is linked to diffuse large B-cell lymphoma.