Such genes up-regulated both in GC-type vs ABC-type DLBCL and in IgA+ vs IgM+ mouse lymphomas, are reminiscent of the observation that GC-type DLBCLs mostly express class-switched BCRs, while ABC-type DLBCLs mostly express IgM [14]. This evidence concerns the gene CD40LG and diffuse large B-cell lymphoma.