LGALS3 and histiocytic sarcoma: Histiocytic sarcoma is relatively common in older C57BL/6 mice and has a similar histologic appearance to the lesions in the huTLR7/8 mice, with infiltrates of round to oval large, monomorphic cells with dark central nuclei and abundant eosinophilic cytoplasm that are Mac-2 and variably F4/80 positive [44], [45], [46], [47].