A more detailed search of the gene set involved in the regulation of TauTKO muscle revealed changes in myopathy-related genes (ANKRD1, CSRP3, TIMP1, ACTC1, AHNAK, CILP, TNFRSF12A, MYL4, IFIT3, MYL3) and UPR-related genes (ATF3, CREM, HSPA5, XBP1) (Fig. 4A). This evidence concerns the gene HSPA5 and myopathy.