Notably, some anti-hypertension therapies have been found to reduce arterial stiffness such as inhibitors of the renin-angiotensin aldosterone system and diuretics but not beta-blockers [24], but more studies, if not new drugs, are needed given that overall, the prevalence of stroke, heart disease, and chronic kidney disease persist higher than expected from the level of reduction in hypertension attained. The gene discussed is REN; the disease is Hypertension.