MMP7 and malignant colon neoplasm: Other noteworthy targets of Wnt signaling include MMP-7 [59], which enhances migration and invasion [60], the normally dormant anti-apoptotic protein Survivin [61], which is reactivated in colon cancer [62], and vascular endothelial growth factor (VEGF), which is important in promoting tumor growth through angiogenesis [63].