We previously reported the critical role of nuclear Nrf2 in the classical 2-stage model of skin carcinogenesis induced by the chemical carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and the tumor promoter TPA in Nrf2 knockout (Nrf2 KO) and wild-type (WT) mice [19]. The gene discussed is NFE2L2; the disease is neoplasm.