SIRT3 and cardiac hypertrophy: Sirt3−/− mice have baseline cardiac hypertrophy evident at 4 or 13 months of age (Sundaresan et al., 2009; Hafner et al., 2010), although data from others show no increase in the cardiac mass of Sirt3−/− mice at 5 months of age (Someya et al., 2010).