These findings are compatible with previous studies of melanoma, renal cell carcinoma and pancreatic cancer, which found that primary cilia loss was independent of Ki67 staining (cell proliferation marker) suggesting that cilia loss is not the result of altered cellular proliferation rates but rather may be due to aberrations in another mechanism that is inherent to ciliogenesis [30-32]. Here, MKI67 is linked to familial pancreatic carcinoma.