GAL and opiate dependence: Other SNPs within the GAL gene region to have been previously implicated in disease susceptibility include rs2187331 (R2 = 0.687 with rs2513280), which has been linked with increased triglyceride levels (16), and rs948854 (R2 = 0.462 with rs2513280) which has shown evidence of association with opioid dependence (Beer et al., 2013).