IGHE and allergic disease: Furthermore, in the era of cost-intensive biologics and increasingly reported use of anti-IgE antibodies in severe allergic diseases, this case highlights the ultimate importance of allergen identification as a crucial therapeutic measure, because avoidance of the causing food antigens induced not only healing of severe ulcer disease as a non-expensive treatment, but also a profound remission of serum IgE and tissue eosinophilia within the gut (Figures 1 and 4).