AKT1 and hepatocellular carcinoma: Moreover, pretreatment with okadaic acid reduced the effects of tamoxifen on apoptosis and p-Akt in tamoxifen-sensitive MDA-MB-231, MDA-MB-468 and MDA-MB-453 cells (Figure 2D), whereas cotreatment with forskolin sensitized HCC-1937 cells to tamoxifen-induced apoptosis and p-Akt downregulation (Figure 2E).