In four representative breast tumor tissues from patients with ER-negative breast cancers with varying degrees (negative, weak, moderate and strong staining) of CIP2A expression, immunohistochemical staining for p-Akt showed that the intensity of nuclear expression for p-Akt correlated with cytoplasmic staining for CIP2A (Figures 5A to 5D). This evidence concerns the gene AKT1 and breast neoplasm.