In this study, we showed that adding a caspase-2 inhibitor diminished apoptosis in poly(I:C)-transfected RCC cells, and that selective knockdown of caspase-2 inhibited both apoptosis and activation of caspase-3, -8, and -9 in poly(I:C)-transfected RCC cells. The gene discussed is CASP3; the disease is renal cell carcinoma.