JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: Taken together, this pre-clinical study provides strong scientific rational for the continued investigation of JAK2 inhibition as a therapeutic strategy in CML and demonstrates the potential merit of combining a highly JAK2-specific inhibitor with potent TKIs to specifically target CML stem/progenitor cells, especially in CML patients likely to develop TKI-resistance if treated with TKI monotherapy.