ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: For example, it is known that BCR-ABL-transduced murine BM cells, transduced using a retroviral transduction model, express much higher levels of BCR-ABL than physiologically primary CML cells from patients’ blood or BM samples and that the role of JAK2 in enhancing cell survival might not be required in these BCR-ABL over-expressing cells, rendering JAK2 dispensable.