AKT1 and acute lymphoblastic leukemia: Importantly, a link between the S1P pathway and major signaling pathways aberrantly activated in T-ALL, such as phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and Ras/Raf/MEK/ERK cascades has been described [19].