Moreover, MPT0G013 significantly induced TIMP3 mRNA and protein expression in endothelial cells and tumor xenografts, and whereas SAHA had a similar pattern of inhibitory activities on HDAC subtypes, it barely induced TIMP3 gene or protein expression in vitro (Supplemental Figure 5A) or in vivo (Supplemental Figure 5B and 5C). The gene discussed is TIMP3; the disease is neoplasm.