HDAC9 and neoplasm: Moreover, MPT0G013 significantly induced TIMP3 mRNA and protein expression in endothelial cells and tumor xenografts, and whereas SAHA had a similar pattern of inhibitory activities on HDAC subtypes, it barely induced TIMP3 gene or protein expression in vitro (Supplemental Figure 5A) or in vivo (Supplemental Figure 5B and 5C).