On the other hand, Imaeda at el has expounded and proved that IL-37 is detected in the inflamed mucosa of IBD patients but not in the health controls [32], Zhong-Yuan Wan at el found that down-regulation of IL-37 expressions appeared to result in over-expression of pro-inflammatory cytokines, such as IL-1β and IL-16 in degenerative intervertebral disc, and they believed that IL-37 may have function to delay the progression of intervertebral disc degeneration [33]. Here, IL37 is linked to Intervertebral disk degeneration.