We focused on major types of B-cell lymphoma (BL, DLBCL ABC, DLBCL GCB, FL and PMBL) and demonstrated that the gene promoters of LRP12 (94%), CDH1 (92%), and BMPER (58%) were methylated at a high frequency, whereas DUSP4 and BMP7 showed lower methylation frequencies (32% and 22%, respectively). The gene discussed is DUSP4; the disease is B-cell non-Hodgkin lymphoma.