SULT1A1 Arg213His polymorphism can increase cancer risks in the following cancer types: breast cancer (homozygous model: OR = 1.37, 95% CI = 1.01–1.87, P = 0.045; dominant model: OR = 1.18, 95% CI = 1.00–1.40, P = 0.050 and allelic model: OR = 1.15, 95% CI = 1.00–1.32, P = 0.044); UADT cancer (heterozygous model: OR = 1.62, 95% CI = 1.11–2.35, P = 0.012; dominant model: OR = 1.63, 95% CI = 1.13–2.35, P = 0.009 and allelic model: OR = 1.52, 95% CI = 1.10–2.11, P = 0.012). This evidence concerns the gene SULT1A1 and cancer.