A previous study evaluated the pharmacokinetics and tissue distribution after oral administration of 3H-galantamine, an AChE inhibitory drug recently developed for Alzheimer's disease, and reported the following ratios of the 0–24 h area under the curve of tissue to plasma; liver (10.6), kidney (7.47), salivary gland (4.45), adrenal gland (3.32), spleen (2.92), and brain (0.60) [9]. This evidence concerns the gene ACHE and Alzheimer disease.