Decreased levels of H3K27me2 and H3K27me3 were associated with reduced levels of EZH2 and increased levels of p16 in nuclear extracts obtained from the marrow cells of two different MDS patients following exposure to 5AZA at 1 μM and DZNep at 1 μM (Figure 6F). Here, EZH2 is linked to myelodysplastic syndrome.