Restriction fragment length polymorphism variation within the non-coding part of exon 4 at this locus, haplotypic characterization of variation in the region and a single change within exon 3 of APOC3 have all been related to either hypertriglyceridemia or familial combined hypercholesterolaemia26, 27, 28. Here, APOC3 is linked to hypertriglyceridemia.