Since first being identified as a BRCA2-interacting protein, Partner and Localizer of BRCA2 (PALB2) has been shown to also interact with BRCA1, effectively bridging these two well-known high-risk breast cancer susceptibility genes and aiding to regulate their function in DNA damage response and homologous recombination [1,2]. This evidence concerns the gene BRCA2 and breast carcinoma.