Recently, in a study investigating the role of combined deletion of hepatic STAT5 and glucocorticoid receptor (GR) in mice, it has been observed that the block of GH and GCs signallings induces lipid accumulation in the liver, which, in turn, contributes to liver chronic inflammation with progression to cirrhosis; this condition subsequently promotes tumorigenic transformation of hepatocytes[79]. The gene discussed is NR3C1; the disease is Cirrhosis.