Although the activation of Stat5 has been associated with tumourigenesis of several solid tumours[75], in the liver, Stat5 has a role as tumour promoter but it seem to have also a potential role as tumour suppressor gene[75,76]; therefore, the role of Stat5 in hepatocarcinogenesis is still debated. The gene discussed is ENSG00000280371; the disease is neoplasm.