In one of these studies, GHR expression has been investigated in 40 different samples of HCC tissues: GHR was undetectable in 5 samples, whereas in the remaining 35 HCC tissues GHR was expressed but it was associated with a lower GH binding ability compared to normal liver[82], suggesting that HCC could be partially resistent to GH stimulation. This evidence concerns the gene GHR and hepatocellular carcinoma.