TPA represents the most abundant cytokeratins pattern in malignant epithelial differentiation.8 The moderate elevation in TPA occurs in some benign events such as liver failure, renal failure, diabetes mellitus and pregnancy.9 The marked elevation of serum TPA is reported in variety of cancers such as breast, lung, gastrointestinal, urological, gynecological cancer, therefore serum level of TPA is valuable as a prognostic marker and for monitoring treatment of patients with different carcinomas.10 The gene discussed is PLAT; the disease is carcinoma.