Several previous studies have indicated that over expression of VEGF is associated with biomarkers of prognosis of patients with osteosarcoma.14-16 However, only one study reported the association between VEGF polymorphisms and prognosis of osteosarcoma in Chinese population.17 Therefore, we conducted a cohort study to investigate the association of three common SNPs of VEGF gene (+1612G/A, -634C/G and +936G/C) with clinical outcome of osteosarcoma in a Chinese population. This evidence concerns the gene VEGFA and osteosarcoma.