VEGF, a growth factor that regulates angiogenesis, is regarded to be the most potent stimulatory cytokine regulating tumor angiogenesis and an important factor in metastasis, survival, and tumor spread.18 In this study, we observed that the VEGF-634CC and +936CC genotype were correlated with a better response to chemotherapy and a longer survival time in OS patients. This evidence concerns the gene VEGFA and neoplasm.