This leads to a major restoration of energy balance by increasing insulin, increasing motivation for palatable food (Piazza and Le Moal, 1997; Dallman et al., 2006; Dallman, 2010), and mobilizing stored energy toward central stores that leads to obesity (Mann and Thakore, 1999). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.