Low levels of another adipose-derived hormone, adiponectin, has been implicated in energy homeostasis, metabolic disturbances, insulin resistance (Kennedy et al., 2006; Hanley et al., 2007; Turer and Scherer, 2012; Hryhorczuk et al., 2013) and recently, depression in humans (Arita et al., 1999; Cnop et al., 2003; Ryo et al., 2004; Leo et al., 2006; Narita et al., 2006; Hanley et al., 2007; Weber-Hamann et al., 2007; Yilmaz, 2008) and rodents (Maeda et al., 2001; Milan et al., 2002; Delporte et al., 2004; Ye et al., 2007). Here, ADIPOQ is linked to major depressive disorder.